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Dacomitinib hydrate

CAS No. 1042385-75-0

Dacomitinib hydrate ( PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804 )

Catalog No. M23250 CAS No. 1042385-75-0

Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 78 In Stock
5MG 119 In Stock
10MG 174 In Stock
25MG 302 In Stock
50MG 453 In Stock
100MG 659 In Stock
500MG 1377 In Stock
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Biological Information

  • Product Name
    Dacomitinib hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases.
  • Description
    Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
  • Synonyms
    PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1042385-75-0
  • Formula Weight
    488.0
  • Molecular Formula
    C24H27ClFN5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4.O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ou SH, Soo RA. Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era? Drug Des Devel Ther. 2015 Oct 15;9:5641-53. doi: 10.2147/DDDT.S52787. eCollection 2015. Review. PubMed PMID: 26508839.
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