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Dacomitinib hydrate
CAS No. 1042385-75-0
Dacomitinib hydrate ( PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804 )
Catalog No. M23250 CAS No. 1042385-75-0
Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 78 | In Stock |
|
| 5MG | 119 | In Stock |
|
| 10MG | 174 | In Stock |
|
| 25MG | 302 | In Stock |
|
| 50MG | 453 | In Stock |
|
| 100MG | 659 | In Stock |
|
| 500MG | 1377 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDacomitinib hydrate
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NoteResearch use only, not for human use.
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Brief DescriptionDacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases.
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DescriptionDacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
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SynonymsPF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number1042385-75-0
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Formula Weight488.0
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Molecular FormulaC24H27ClFN5O3
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4.O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ou SH, Soo RA. Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era? Drug Des Devel Ther. 2015 Oct 15;9:5641-53. doi: 10.2147/DDDT.S52787. eCollection 2015. Review. PubMed PMID: 26508839.
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