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Dacomitinib hydrate

CAS No. 1042385-75-0

Dacomitinib hydrate ( PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804 )

Catalog No. M23250 CAS No. 1042385-75-0

Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 78 In Stock
5MG 119 In Stock
10MG 174 In Stock
25MG 302 In Stock
50MG 453 In Stock
100MG 659 In Stock
500MG 1377 In Stock
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Biological Information

  • Product Name
    Dacomitinib hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases.
  • Description
    Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
  • Synonyms
    PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1042385-75-0
  • Formula Weight
    488.0
  • Molecular Formula
    C24H27ClFN5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4.O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ou SH, Soo RA. Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era? Drug Des Devel Ther. 2015 Oct 15;9:5641-53. doi: 10.2147/DDDT.S52787. eCollection 2015. Review. PubMed PMID: 26508839.
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